The glory of God denotes weight and substance.
This perfectly comports with God's aseity as being the foundation of man's every conception of God.
Ontologically, God IS. He is not derived from, or an instance of, a generic and abstract "God" being, but is Himself the self-existent Triune God and the source of all created being.
Epistemologically, man's knowledge of anything, if it is to be "of substance," must reckon with the Creator of the fact being apprehended.
Morally, one's lifestyle, and the worldview which informs and influences this, if it is to be "weighty" and truly significant, must have the glory of God as Creator and Redeemer at the forefront of its consideration.
As you can see, the glory of God is God Himself, and the pursuit of His glory is the pursuit of His Son, the Lord Jesus Christ, for "long ago, at many times and in many ways, God spoke to our fathers by the prophets, but in these last days he has spoken to us by his Son, whom he appointed the heir of all things, through whom also he created the world. He is the radiance of the glory of God and the exact imprint of his nature, and he upholds the universe by the word of his power. After making purification for sins, he sat down at the right hand of the Majesty on high, having become as much superior to angels as the name he has inherited is more excellent than theirs (Hebrews 1:1-4)."
And we will share in His glory:
"Furthermore, other passages in this last part of Isaiah suggest that the presence of God's glory will render the people of God glorious (see 62:2). What does it mean that the people will be glorious? After their purification by judgment, they can reflect God's glory. Their glory is not inherent to them but is reflected—as the moon reflects the light of the sun, so the people of God reflect the glory of their Lord. Thanks to the work of God, God's people are 'heavy' with significance. God's people will be a 'crown of beauty' and a 'royal diadem' (62:3). They have substance and reputation ('you shall be called by a new name,' 62:2). God's blessing will also bring them substance. Their glory primarily serves a missionary purpose, as the nations will see this glory and be attracted to it." (Tremper Longman III, 'The Glory of God in the Old Testament', The Glory of God [Theology in Community] [Illinois: Crossway, 2010], eds. Christopher W. Morgan & Robert A. Peterson, p. 69)
Man, as made in the image of God, was not made for fluffy, floaty stuff. It can then be argued that the antithesis may also be described as humanity that is defined either by hollow weightlessness or substantial heaviness.